The Holy Grail of intellectual thought since there has been intellectual thought is the TOE, Theory Of Everything, the singular theory that will explain everything, unite everything, and allow us to manage everything. This can also feed into the age old Utopian impulse. If we could just get a handle on everything, we could get everything put together right, and get ourselves back to the Garden.
But life is messy and people and their interactions are complicated. In order to get a TOE that is comprehensible, people and their interactions must be simplified. Every adequately simplified accounting for everything ends up an over simplification that leaves out crucial factors and the resulting TOE becomes a Procrustean bed. Marx reduced everything to economics, laissez-faire capitalism reduces everything to market forces, post-modernism to power, and now white fragility to race. The problem is that each of these schema does capture an accurate picture of part of the whole, the difficulty is that they only describe part and attempt to stretch or chop the rest of reality to fit their part.
And the cherubim still block the way back to the garden. Another Way, Truth, and Life is needed.