That said, I do hope the Republicans are more responsible than the Democrats were in dealing with cabinet appointees. The longtime "rule" has been that a President is entitled to choose his advisors, unless they are totally bonkers. Only about 5 of Trump's were confirmed with what was essentially a strong bipartisan vote (though all were confirmed). I hope Republicans act more grown up than that.
I would personally like to see one or both of two things happen. First, I think Biden should sit down with McConnell (with whom he served in the Senate for decades) and say, "Look, we need to address this partisan polarization. Let's figure out how we can avoid party-line votes as much as possible, and try to get some things done." Second, I think the handful of GOP Senators who have demonstrated concern about this issue (Romney, Collins, Murkowski, maybe Sasse and a few others) should say to McConnell, "We're not going to play these games any more. We need to tone down the partisan divisiveness."
All of this also, of course, presupposes that Biden tries to govern as he campaigned, as a moderate who wants to tone down the divisiveness and overcome the gridlock. So no cabinet post for AOC, etc.
Alas, I don't really think any of those things will happen--in part because, though Trump has (apparently) been defeated, Trumpism has not, and there is a strong and vocal group that will start screaming "RINO" at any GOP Senator who tries to work with Biden. (There are also leftie Dems who will complain about Biden working with McConnell, but I think he will be more resistant to them; after all, he's the president, and I seriously doubt he's thinking about needing to run again.)